The response to receiving phenotypic and genetic coronary heart disease risk scores and lifestyle advice – a qualitative study

BACKGROUND: Individuals routinely receive information about their risk of coronary heart disease (CHD) based on traditional risk factors as part of their primary care. We are also able to calculate individual's risk of CHD based on their genetic information and at present genetic testing for common diseases is available to the public. Due to the limitations in previous studies further understanding is needed about the impact of the risk information on individual's well-being and health-behaviour. We aimed to explore the short term response to receiving different forms of CHD risk information and lifestyle advice for risk reduction. METHODS: We conducted fourty-one face-to-face interviews and two focus groups across England with participants from the INFORM trial who received a combination of individualised phenotypic and genotypic CHD risk scores and web-based lifestyle advice. Risk scores were presented in different formats, e.g. absolute 10 year risk was presented as a thermometer and expressed as a percentage, natural frequency and 'heart age'. Interviews and focus groups explored participants' understanding and reaction to the risk scores and attempts to change lifestyle during the intervention. We tape-recorded and transcribed the interviews and focus groups and analysed them using thematic analysis. RESULTS: Three main themes were identified: limitations of risk scores to generate concern about CHD risk; the advantages of the 'heart age' format of risk score presentation in communicating a message of sub-optimal lifestyle; and intentions and attempts to make moderate lifestyle changes which were prompted by the web-based lifestyle advice. CONCLUSIONS: There are a number of limitations to the use of risk scores to communicate a message about the need for a lifestyle change. Of the formats used, the 'heart age', if noticed, appears to convey the most powerful message about how far from optimal risk an individual person is. An interactive, user friendly, goal setting based lifestyle website can act as a trigger to initiate moderate lifestyle changes, regardless of concerns about risk scores.INFORM is funded by European Commission Framework 7 EPIC-CVD Grant agreement no: 279233. NHS Blood and Transplant funded the INTERVAL trial. DNA extraction and genotyping in INTERVAL/INFORM was funded by the UK National Institute of Health Research. The coordinating team for INTERVAL/INFORM at the Cardiovascular Epidemiology Unit of the University of Cambridge was supported by core funding from: UK Medical Research Council (G0800270), British Heart Foundation (SP/09/002), British Heart Foundation Cambridge Cardiovascular Centre of Excellence, and UK National Institute for Health Research Cambridge Biomedical Research Centre

Single-particle and collective excitations in a charged Bose gas at finite temperature

The main focus of this work is on the predictions made by the dielectric formalism in regard to the relationship between single-particle and collective excitation spectra in a gas of point-like charged bosons at finite temperature $T$ below the critical region of Bose-Einstein condensation. Illustrative numerical results at weak coupling ($r_s = 1$) are presented within the Random Phase Approximation. We show that within this approach the single-particle spectrum forms a continuum extending from the transverse to the longitudinal plasma mode frequency and leading to a double-peak structure as $T$ increases, whereas the density fluctuation spectrum consists of a single broadening peak. We also discuss the momentum distribution and the superfluidity of the gas.Comment: 15 pages, 5 figure

Numerical calculations of a high brilliance synchrotron source and on issues with characterizing strong radiation damping effects in non-linear Thomson/Compton backscattering experiments

A number of theoretical calculations have studied the effect of radiation reaction forces on radiation distributions in strong field counter-propagating electron beam-laser interactions, but could these effects - including quantum corrections - be observed in interactions with realistic bunches and focusing fields, as is hoped in a number of soon to be proposed experiments? We present numerical calculations of the angularly resolved radiation spectrum from an electron bunch with parameters similar to those produced in laser wakefield acceleration experiments, interacting with an intense, ultrashort laser pulse. For our parameters, the effects of radiation damping on the angular distribution and energy distribution of \emph{photons} is not easily discernible for a "realistic" moderate emittance electron beam. However, experiments using such a counter-propagating beam-laser geometry should be able to measure such effects using current laser systems through measurement of the \emph{electron beam} properties. In addition, the brilliance of this source is very high, with peak spectral brilliance exceeding $10^{29}$ photons$\,$s$^{-1}$mm$^{-2}$mrad$^{-2}(0.1$% bandwidth$)^{-1}$ with approximately 2% efficiency and with a peak energy of 10 MeV.Comment: 11 figures, 11 page

Using White Dish CMB Anisotropy Data to Probe Open and Flat-Lambda CDM Cosmogonies

We use data from the White Dish experiment to set limits on cosmic microwave background radiation anisotropies in open and spatially-flat-Lambda cold dark matter cosmogonies. We account for the White Dish calibration uncertainty, and marginalize over the offset and gradient removed from the data. Our 2-sigma upper limits are larger than those derived previously. These upper limits are consistent with those derived from the $COBE$-DMR data for all models tested.Comment: 17 pages of latex. Uses aasms4.sty. 4 figures included. Submitted to ApJ

First Results from SPARO: Evidence for Large-Scale Toroidal Magnetic Fields in the Galactic Center

We have observed the linear polarization of 450 micron continuum emission from the Galactic center, using a new polarimetric detector system that is operated on a 2 m telescope at the South Pole. The resulting polarization map extends ~ 170 pc along the Galactic plane and ~ 30 pc in Galactic latitude, and thus covers a significant fraction of the central molecular zone. Our map shows that this region is permeated by large-scale toroidal magnetic fields. We consider our results together with radio observations that show evidence for poloidal fields in the Galactic center, and with Faraday rotation observations. We compare all of these observations with the predictions of a magnetodynamic model for the Galactic center that was proposed in order to explain the Galactic Center Radio Lobe as a magnetically driven gas outflow. We conclude that the observations are basically consistent with the model.Comment: 11 pages, 2 figures, 1 table, submitted to ApJ Let

24 Command Fire Improvement Action Program Plan

Fluor Hanford (FH) is responsible for providing support to the Department of Energy Richland Operations Office (RL) in the implementation of the Hanford Emergency Preparedness (EP) program. During fiscal year 2000, a number of program improvements were identified from various sources including a major range fire (24 Command Fire). Evaluations of the emergency preparedness program have confirmed that it currently meets all requirements and that performance of personnel involved is good, however the desire to effect continuous improvement resulted in the development of this improvement program plan. This program plan defines the activities that will be performed in order to achieve the desired performance improvements

Design and performance of feedhorn-coupled bolometer arrays for SPIRE

This paper reviews the design, modeling, and testing of feedhorn arrays coupled to bolometric detector arrays being developed for the ESA Herschel Space Observatory's SPIRE instrument. SPIRE will incorporate five arrays of silicon nitride micromesh bolometers, in three broadband photometers and two Fourier-Transform spectrometers covering 200-700 μm, with a total of 326 feedhorn-coupled bolometers. The precision feedhorn arrays are formed by close-packing individually fabricated conical feedhorns, which terminate in waveguides and integrating cavities. The detector array is efficiently packaged by mounting it between a metallized silicon backshort array and the feedhorn array, which encloses the bolometers in precisely tuned integrating cavities. The absorption efficiency, bandwidth, and cross talk were first investigated with numerical simulations of the electromagnetic fields, and then measured for prototype arrays in a test facility. This discussion describes the design goals, simulations, fabrication, and measurements of optical efficiencies, spectral properties, beam shapes, and cross talk between bolometers